Biomedical fields have seen a remarkable increase in hybrid Gold open access articles. However, it is uncertain whether the hybrid Gold open access option contributes to a citation advantage, an increase in the citations of articles made immediately available as open access regardless of the article’s quality or whether it involves a trending topic of discussion. This study aimed to compare the citation counts of hybrid Gold open access articles to subscription articles published in hybrid journals. The study aimed to ascertain if hybrid Gold open access publications yield an advantage in terms of citations. This cross-sectional study included the list of hybrid journals under 59 categories in the "Clinical Medicine" group from Clarivate’s Journal Citation Reports (JCR) during 2018–2021. The number of citable items with ‘Gold Open Access’ and ‘Subscription and Free to Read’ in each journal, as well as the number of citations of those citable items, were extracted from JCR. A hybrid Gold open access citation advantage was computed by dividing the number of citations per citable item with hybrid Gold open access by the number of citations per citable item with a subscription. A total of 498, 636, 1009, and 1328 hybrid journals in the 2018 JCR, 2019 JCR, 2020 JCR, and 2021 JCR, respectively, were included in this study. The citation advantage of hybrid Gold open access articles over subscription articles in 2018 was 1.45 (95% confidence interval (CI), 1.24–1.65); in 2019, it was 1.31 (95% CI, 1.20–1.41); in 2020, it was 1.30 (95% CI, 1.20–1.39); and in 2021, it was 1.31 (95% CI, 1.20–1.42). In the ‘Clinical Medicine’ discipline, the articles published in the hybrid journal as hybrid Gold open access had a greater number of citations when compared to those published as a subscription, self-archived, or otherwise openly accessible option.